Jiwoon Park

New York, USA · jip2007@med.cornell.edu
Ph.D. in Physiology, Biophysics, and Systems Biology @ Weill Cornell Graduate School, Cornell University

Interested in multi-omics modelling of liver immune microenvironment activation & fate decisions upon injury.

Ongoing research projects include:
  • Systemic Tissue and Cellular Disruption from COVID-19 Autopsy Tissues and Lung Spatial Transcriptomics Analyses
  • hPSC-derived multicellular liver model to understand changes during liver disease progression
  • epigenetic changes in HSC activation-regression and its influence to subsequent stimulation and fibrosis resolution
  • Development of injury-specific gene signatures and HCC risk scoring algorithm

Experience

ROCEKFELLER UNIVERSITY, New York, NY

Graduate Student, Laboratory of virology and infectious disease, advised by Charles M. Rice

Currently working on developing human pluripotent stem cell derived liver co-culture platform to model liver pathogenesis and disease progression. Previously investigated transcriptome-level changes of liver immune environment upon hepatitis C virus infection using single cell RNA sequencing technology.

July 2019 - May 2023

CENTER FOR GENOMIC MEDICINE, WEILL CORNELL MEDICINE, New York, NY

Graduate Student, advised by Christopher E. Mason

Investigated SARS-CoV-2 infection spatial transcriptomics and performed systems-level analyses using postmortem patient lung, liver, heart, kidney, and lymph nodes from COVID-19 as well as other lung diseases Compared different m5C RNA methylation analysis toolkits and optimized data analysis pipeline and characterized methylation patterns in snail, twist, and TGFbeta-overexpressed markers in the context of epithelial to mesenchymal transition process.

July 2019 - May 2023

BELFER RESEARCH CENTER, WEILL CORNELL MEDICINE, New York, NY

Lab manager/technician, Medicine: Gastroenterology & Hepatology Division, advised by Robert E. Schwartz

Investigated factors affecting the functionality of human primary hepatocytes in cultures, using different culture techniques such as 2D micro-patterned, collagen-coated plates and 3D PDMS micro-well aggregates and co-culture techniques. Also created embryonic bodies from stem cell generated from non-human primate fibroblasts to model differentiation and compared with human stem cell derived differentiations.

Master’s Degree Thesis: co-advised by Ruben Savizky and Robert E Schwartz

Thesis: Using CRISPR-Cas9 for Characterization of Developmental Markers in Differentiation of Hepatocyte. Investigated novel implementations of CRISPR-Cas9 technology to label and characterize differentiation process of the induced pluripotent stem cells to hepatocytes.

July 2015 - June 2019

Education

Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY

Doctor of Philosophy (Ph.D.), in Physiology, Biophysics, and Systems Biology

Advised by Drs. Charles M. Rice & Christopher E. Mason

July 2019 - May 2023

The Cooper Union for the Advancement of Science and Art, New York, NY

Master of Engineering (M.Eng.), in Chemical Engineering

Advised by Dr. Ruben Savizky

Bachelor of Engineering (B.Eng.), in Chemical Engineering (minor in Biomedical Engineering)

Cum Laude, Full-tuition scholarship, Dean's List, Omega Chi Epsilon

August 2013 - May 2017

Skills

Computational biology

Spatial Transcriptomics, Bulk and single cell RNA-seq, Bulk and single cell ATAC-seq, 10x Multiome GEX+ATAC, Multiomic data integration and modeling

Experimental biology

Stem cell and organoid cultures, Differentiation (liver cell types), 2D micropatterning/3D cultures, Microfluidic devices

Interests

To be updated

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Awards & Certifications

  • MOGAM Science Fellowship, MOGAM Science Scholarship Foundation (2022)
  • KSEA-KUSCO graduate scholarship, Korea-US Science Cooperation Center (KUSCO) (2022)
  • KSEA Scholarship Recipient, Korean American Scientists and Engineers Association (2016)
  • William H. Nichols Fellowship, American Chemical Society (2016)
  • Competent Communicator and Competent Leadership Qualification, Toastmasters International (2016)
  • Gold in Foundational Advances, International Genetically Modified Machine Competition (2014)
  • Certificate of Excellence, The Korean Federation of Science and Technology Societies (2014)
  • Dean’s List, The Cooper Union for the Advancement of Science and Art (2013, 15-17)
  • Full-tuition Scholarship, The Cooper Union for the Advancement of Science and Art (2013-17)